Co-mutations of epidermal growth factor receptor and BRAF in Chinese non-small cell lung cancer patients.

ABSTRACT:

Background

Epidermal growth factor receptor (EGFR) and BRAF are 2 driver genes in non-small cell lung cancer (NSCLC) which are normally mutually exclusive. It has been previously reported that the existence of BRAF V600E in EGFR-mutated NSCLC patients could cause resistance to EGFR tyrosine kinase inhibitors (TKIs), but the influence of other BRAF actionable mutations on resistance to EGFR-TKIs has not yet been investigated. Understanding the coexistence of EGFR and BRAF actionable mutations in Chinese NSCLC patients may be essential for further treatment and prognostic prediction.

Methods

A total of 127 Chinese NSCLC patients harboring EGFR and BRAF co-mutations were enrolled in this study. We analyzed the mutation profiles of these patients through next-generation sequenci

SUBMITTER: Peng P 

PROVIDER: S-EPMC8422152 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature