GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma.

ABSTRACT:

Background

A better understanding of the molecular mechanisms that manifest in the immunosuppressive tumor microenvironment (TME) is crucial for developing more efficacious immunotherapies for hepatocellular carcinoma (HCC), which has a poor response to current immunotherapies. Regulatory T (Treg) cells are key mediators of HCC-associated immunosuppression. We investigated the selective mechanism exploited by HCC that lead to Treg cells expansion and to find more efficacious immunotherapies.

Methods

We used matched tumor tissues and blood samples from 150 patients with HCC to identify key factors of Treg cells expansion. We used mass cytometry (CyTOF) and orthotopic cancer mouse models to analyze overall immunological changes after growth differentiation factor 15 (GDF15) ge

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8422483 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature