Neuromedin U induces an invasive phenotype in CRC cells expressing the NMUR2 receptor.

ABSTRACT:

Background

Successful colorectal cancer (CRC) therapy often depends on the accurate identification of primary tumours with invasive potential. There is still a lack of identified pathological factors associated with disease recurrence that could help in making treatment decisions. Neuromedin U (NMU) is a secretory neuropeptide that was first isolated from the porcine spinal cord, and it has emerged as a novel factor involved in the tumorigenesis and/or metastasis of many types of cancers. Previously associated with processes leading to CRC cell invasiveness, NMU has the potential to be a marker of poor outcome, but it has not been extensively studied in CRC.

Methods

Data from The Cancer Genome Atlas (TCGA) were used to analyse NMU and NMU receptor (NMUR1 and NMUR2) expressio

SUBMITTER: Przygodzka P 

PROVIDER: S-EPMC8422652 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature