Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway.

ABSTRACT:

Background

Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether pinocembrin was able to ameliorate post-infarct heart failure (PIHF) and the underlying mechanisms.

Methods

Rats were carried out left anterior descending artery ligation to induce myocardial infarction and subsequently raised for 6 weeks to produce chronic heart failure. Then pinocembrin was administrated every other day for 2 weeks. The effects were evaluated by echocardiography, western blot, Masson's staining, biochemical examinations, immunohistochemistry, and fluorescence. In vitro we also cultured H9c2 cardiomyocytes and cardiac myofibroblasts to further testify the mechanisms.

Results

We found that PIHF-induced de

SUBMITTER: Chen X 

PROVIDER: S-EPMC8422663 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature