Interferon regulatory factor family influences tumor immunity and prognosis of patients with colorectal cancer.

ABSTRACT:

Background

Since interferon regulatory factor (IRF) family functions in immune response to viral infection, its role in colorectal cancer (CRC) has not been inspected before. This study tries to investigate members of IRF family using bioinformatics approaches in aspect of differential expressions, biological function, tumor immune infiltration and clinical prognostic value for patients with CRC.

Methods

Transcriptome profiles data, somatic mutations and clinical information of CRC were obtained from COAD/READ dataset of The Cancer Genome Atlas (TCGA) as a training set. Gene expression data (GSE17536 and GSE39582) were downloaded from the Gene Expression Omnibus as a validating set. A random forest algorithm was used to score the risk for every case. Analyzing gene and funct

SUBMITTER: Chen YJ 

PROVIDER: S-EPMC8422700 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature