Salivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging.

ABSTRACT:

Background

Aging is associated with declining protective immunity and persistent low-grade inflammatory responses, which significantly contribute to Alzheimer's disease (AD) pathogenesis. Detecting aging-related cerebral vulnerability associated with deterioration of the immune system requires from non-invasive biomarkers able to detect failures in the brain-immunity connection. Reduced levels of salivary lactoferrin (sLF), an iron-binding protein with immunomodulatory activity, have been related to AD diagnosis. However, it remains unknown whether decreased sLF is associated with increased cortical amyloid-beta (Aβ) load and/or with loss of cortical integrity in normal aging.

Methods

Seventy-four cognitively normal older adults (51 females) participated in the study. We app

SUBMITTER: Reseco L 

PROVIDER: S-EPMC8422723 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature