The effect of CYP7B1 polymorphisms on the risk of coronary heart disease in Hainan Han population.

ABSTRACT:

Background

Coronary heart disease (CHD) is the leading cause of human death worldwide. Genetic factors play an important role in the occurrence of CHD. Our study is designed to investigate the influence of CYP7B1 polymorphisms on CHD risk.

Methods

In this case-control study, 508 CHD patients and 510 healthy individuals were recruited to determine the correlation between CYP7B1 polymorphisms (rs7836768, rs6472155, and rs2980003) and CHD risk. The associations were evaluated by computing odds ratios (OR) and 95% confidence intervals (CI) with logistic regression analysis. The association between SNP-SNP interaction and CHD susceptibility was carried out by multifactor dimensionality reduction analyses.

Results

Our study found that rs6472155 is significantly associated w

SUBMITTER: Liang T 

PROVIDER: S-EPMC8422734 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature