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Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer.

ABSTRACT: Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling PTEN, RB1, and TP53 genetic loss in metastatic prostate cancer patients.

SUBMITTER: Dong X 

PROVIDER: S-EPMC8422845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Circulating Cell-Free DNA-Based Detection of Tumor Suppressor Gene Copy Number Loss and Its Clinical Implication in Metastatic Prostate Cancer.

Dong Xiaoxi X   Zheng Tiantian T   Zhang Minhua M   Dai Chao C   Wang Lili L   Wang Lei L   Zhang Ruipeng R   Long Yuan Y   Wen Danyi D   Xie Feng F   Zhang Yue Y   Huang Yong Y   Dong Jianguo J   Liu Huan H   Du Pan P   King Bonnie L BL   Tan Winston W   Jia Shidong S   Lu Chris X CX   Kohli Manish M   Wang Haitao H   Yu Jianjun J  

Frontiers in oncology 20210824

Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with improved sensitivity for detection of copy number loss in blood samples with low levels of circulating tumor DNA, and demonstrate its utility by profiling <i>PTEN</i>, <i>RB1</i>, and <i>TP53</i> genetic loss in metastatic prostate cancer patients. ...[more]

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