High-Frequency Oscillations in the Pallidum: A Pathophysiological Biomarker in Parkinson's Disease?

ABSTRACT:

Background

Abnormal oscillatory neural activity in the beta-frequency band (13-35 Hz) is thought to play a role in Parkinson's disease (PD); however, increasing evidence points to alterations in high-frequency ranges (>100 Hz) also having pathophysiological relevance.

Objectives

Studies have found that power in subthalamic nucleus (STN) high-frequency oscillations is increased with dopaminergic medication and during voluntary movements, implicating these brain rhythms in normal basal ganglia function. The objective of this study was to investigate whether similar signaling occurs in the internal globus pallidus (GPi), a nucleus increasingly used as a target for deep brain stimulation (DBS) for PD.

Methods

Spontaneous and movement-related GPi field potentials were reco

SUBMITTER: Johnson LA 

PROVIDER: S-EPMC8422942 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature