Exploration of antigenic determinants in spike glycoprotein of SARS-CoV2 and identification of five salient potential epitopes.

ABSTRACT: Emerging pathogens have been an eternal threat to mankind. In a series of pandemics caused by notorious coronaviruses, a newly emerged SARS-CoV2 virus is creating panic among the world population. The unavailability of reliable theranostics insists the exploration of antigenic determinants in spike glycoprotein of SARS-CoV2. The four novel inserts ('⁷⁰VSGTNGT⁷⁶', '¹⁵⁰KSWM¹⁵³', ²⁴⁷SYLTPG²⁵² and ⁶⁷⁴QTQTNSPRR⁶⁸²) in SARS-CoV2 spike protein were unraveled via multiple sequence alignment of spike proteins of SARS-CoV2, SARS-CoV, and MERS-CoV. The three-dimension (3D) modeling of the spike protein of the SARS-CoV2 and their interaction with the ACE2 receptor was delineated with the help of SWISS-MODEL and 3DL

SUBMITTER: Agrawal A 

PROVIDER: S-EPMC8422955 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature