Antibiotics Shift the Temperature Response Curve of Escherichia coli Growth.

ABSTRACT: Temperature variation-through time and across climatic gradients-affects individuals, populations, and communities. Yet how the thermal response of biological systems is altered by environmental stressors is poorly understood. Here, we quantify two key features-optimal temperature and temperature breadth-to investigate how temperature responses vary in the presence of antibiotics. We use high-throughput screening to measure growth of Escherichia coli under single and pairwise combinations of 12 antibiotics across seven temperatures that range from 22°C to 46°C. We find that antibiotic stress often results in considerable changes in the optimal temperature for growth and a narrower temperature breadth. The direction of the optimal temperature shifts can be explained by the similarities betw

SUBMITTER: Cruz-Loya M 

PROVIDER: S-EPMC8422994 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature