Waning of Measured Influenza Vaccine Effectiveness Over Time: The Potential Contribution of Leaky Vaccine Effect.

ABSTRACT:

Background

Several observational studies have shown decreases in measured influenza vaccine effectiveness (mVE) during influenza seasons. One study found decreases of 6-11%/month during the 2011-2012 to 2014-2015 seasons. These findings could indicate waning immunity but could also occur if vaccine effectiveness is stable and vaccine provides partial protection in all vaccinees ("leaky") rather than complete protection in a subset of vaccinees. Since it is unknown whether influenza vaccine is leaky, we simulated the 2011-2012 to 2014-2015 influenza seasons to estimate the potential contribution of leaky vaccine effect to the observed decline in mVE.

Methods

We used available data to estimate daily numbers of vaccinations and infections with A/H1N1, A/H3N2, and B viruses. We

SUBMITTER: Tokars JI 

PROVIDER: S-EPMC8422999 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature