The fecal microbiome and rotavirus vaccine immunogenicity in rural Zimbabwean infants.

ABSTRACT:

Background

Oral rotavirus vaccine (RVV) immunogenicity is considerably lower in low- versus high-income populations; however, the mechanisms underlying this remain unclear. Previous evidence suggests that the gut microbiota may contribute to differences in oral vaccine efficacy.

Methods

We performed whole metagenome shotgun sequencing on stool samples and measured anti-rotavirus immunoglobulin A in plasma samples from a subset of infants enrolled in a cluster randomized 2 × 2 factorial trial of improved water, sanitation and hygiene and infant feeding in rural Zimbabwe (SHINE trial: NCT01824940). We examined taxonomic microbiome composition and functional metagenome features using random forest models, differential abundance testing and regression analyses to explored associ

SUBMITTER: Robertson RC 

PROVIDER: S-EPMC8423000 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature