Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors.

ABSTRACT: Assigning behavioral roles to genetically defined neurons within the lateral hypothalamus (LH) is an ongoing challenge. We demonstrate that a subpopulation of LH GABAergic neurons expressing leptin receptors (LH^LEPR) specifically drives appetitive behaviors in mice. Ablation of LH GABAergic neurons (LH^VGAT) decreases weight gain and food intake, whereas LH^LEPR ablation does not. Appetitive learning in a Pavlovian conditioning paradigm is delayed in LH^VGAT-ablated mice but prevented entirely in LH^LEPR-ablated mice. Both LH^VGAT and LH^LEPR neurons bidirectionally modulate reward-related behaviors, but only LH^VGAT neurons affect feeding. In the Pavlovian paradigm, only LH^LEPR activity discriminat

SUBMITTER: Siemian JN 

PROVIDER: S-EPMC8423025 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature