Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge.

ABSTRACT: Early events in the host response to SARS-CoV-2 are thought to play a major role in determining disease severity. During pulmonary infection, the virus encounters both myeloid and epithelioid lineage cells that can either support or restrict pathogen replication as well as respond with host protective versus detrimental mediators. In addition to providing partial protection against pediatric tuberculosis, vaccination with bacille Calmette-Guérin (BCG) has been reported to confer non-specific resistance to unrelated pulmonary pathogens, a phenomenon attributed to the induction of long-lasting alterations within the myeloid cell compartment. Here we demonstrate that prior intravenous, but not subcutaneous, administration of BCG protects human-ACE2 transgenic mice against lethal challenge wit

SUBMITTER: Hilligan KL 

PROVIDER: S-EPMC8423217 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature