Microbiota composition and mucosal immunity in patients with asymptomatic diverticulosis and controls.

ABSTRACT:

Introduction

The etiology of diverticulosis is still poorly understood. However, in patients with diverticulitis, markers of mucosal inflammation and microbiota alterations have been found. The aim of this study was to evaluate potential differences of the gut microbiota composition and mucosal immunity between patients with asymptomatic diverticulosis and controls.

Methods

We performed a prospective study on patients who underwent routine colonoscopy for causes not related to diverticular disease or inflammatory bowel disease. Participants were grouped based on the presence or absence of diverticula. Mucosal biopsies were obtained from the sigmoid and transverse colon. Microbiota composition was analyzed with IS-pro, a 16S-23S based bacterial profiling technique. To predict

SUBMITTER: van Rossen TM 

PROVIDER: S-EPMC8423250 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature