NSAID use is not associated with Parkinson's disease incidence: A Norwegian Prescription Database study.

ABSTRACT:

Objective

Whether use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of incident Parkinson's disease (PD) remains unresolved. Here, we employed the Norwegian Prescription Database to examine whether NSAID use is associated with a lower incidence of PD.

Methods

We compared the incidence of PD among users of NSAIDs in a population-based retrospective study using the Norwegian Prescription Database from 2004 to 2017. In total 7580 PD patients were identified using dopaminergic therapy over time as proxy for PD diagnosis. Analyses were performed with minimum 90 and 365 defined daily dose (DDD) NSAID exposure, respectively. Time-dependent Cox regression model and a binary logistic regression analysis with a 5-year lag until PD diagnosis were performed for all NS

SUBMITTER: Brakedal B 

PROVIDER: S-EPMC8423296 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature