Pathology-specific experimental antivenoms for haemotoxic snakebite: The impact of immunogen diversity on the in vitro cross-reactivity and in vivo neutralisation of geographically diverse snake venoms.

ABSTRACT:

Background

Snakebite is a neglected tropical disease that causes high global rates of mortality and morbidity. Although snakebite can cause a variety of pathologies in victims, haemotoxic effects are particularly common and are typically characterised by haemorrhage and/or venom-induced consumption coagulopathy. Antivenoms are the mainstay therapeutic for treating the toxic effects of snakebite, but despite saving thousands of lives annually, these therapies are associated with limited cross-snake species efficacy due to venom variation, which ultimately restricts their therapeutic utility to particular geographical regions.

Methodology/principal findings

In this study we explored the feasibility of generating globally effective pathology-specific antivenoms to counteract th

SUBMITTER: Alomran N 

PROVIDER: S-EPMC8423360 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature