CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice.

ABSTRACT: More humans have died of tuberculosis (TB) than any other infectious disease and millions still die each year. Experts advocate for blood-based, serum protein biomarkers to help diagnose TB, which afflicts millions of people in high-burden countries. However, the protein biomarker pipeline is small. Here, we used the Diversity Outbred (DO) mouse population to address this gap, identifying five protein biomarker candidates. One protein biomarker, serum CXCL1, met the World Health Organization's Targeted Product Profile for a triage test to diagnose active TB from latent M.tb infection (LTBI), non-TB lung disease, and normal sera in HIV-negative, adults from South Africa and Vietnam. To find the biomarker candidates, we quantified seven immune cytokines and four inflammatory proteins corresp

SUBMITTER: Koyuncu D 

PROVIDER: S-EPMC8423361 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature