Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model.

ABSTRACT: Dietary changes associated with industrialization increase the prevalence of chronic diseases, such as obesity, type II diabetes, and cardiovascular disease. This relationship is often attributed to an 'evolutionary mismatch' between human physiology and modern nutritional environments. Western diets enriched with foods that were scarce throughout human evolutionary history (e.g. simple sugars and saturated fats) promote inflammation and disease relative to diets more akin to ancestral human hunter-gatherer diets, such as a Mediterranean diet. Peripheral blood monocytes, precursors to macrophages and important mediators of innate immunity and inflammation, are sensitive to the environment and may represent a critical intermediate in the pathway linking diet to disease. We evaluated the eff

SUBMITTER: Johnson CSC 

PROVIDER: S-EPMC8423447 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature