Mammographic features are associated with cardiometabolic disease risk and mortality.

ABSTRACT:

Aims

In recent years, microcalcifications identified in routine mammograms were found to be associated with cardiometabolic disease in women. Here, we aimed to systematically evaluate the association of microcalcifications and other mammographic features with cardiometabolic disease risk and mortality in a large screening cohort and to understand a potential genetic contribution.

Methods and results

This study included 57 867 women from a prospective mammographic screening cohort in Sweden (KARMA) and 49 583 sisters. Cardiometabolic disease diagnoses and mortality and medication were extracted by linkage to Swedish population registries with virtually no missing data. In the cardiometabolic phenome-wide association study, we found that a higher number of microcalcifications

SUBMITTER: Grassmann F 

PROVIDER: S-EPMC8423470 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature