Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar.

ABSTRACT:

Objectives

To explore the effective and safe medicines for treating diabetes.

Methods

Hydroalcoholic extracts of 130 medicinal plants belonging to 66 families were evaluated using porcine pancreatic lipase (PPL) inhibition and glucose uptake methods together with a literature review.

Results

The extracts of 22 species showed the PPL inhibition activity; 18 extracts of 15 species stimulated glucose uptake in 3T3-L1 adipocytes. Among them, Mansonia gagei J.R. Drumm., Mesua ferrea L., and Centella asiatica (L.) Urb. exhibited both activities. The extracts of Caladium lindenii (André) Madison rhizomes and Azadirachta indica A. Juss. leaves presented the utmost lipase inhibitory activity with IC₅₀ of 6.86 ± 0.25 and 11.46 ± 0.0

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8423552 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature