Pharmacodynamic analysis of a fluid challenge with 4 ml kg^-1 over 10 or 20 min: a multicenter cross-over randomized clinical trial.

ABSTRACT:

Purpose

A number of studies performed in the operating room evaluated the hemodynamic effects of the fluid challenge (FC), solely considering the effect before and after the infusion. Few studies have investigated the pharmacodynamic effect of the FC on hemodynamic flow and pressure variables. We designed this trial aiming at describing the pharmacodynamic profile of two different FC infusion times, of a fixed dose of 4 ml kg^-1.

Methods

Forty-nine elective neurosurgical patients received two consecutive FCs of 4 ml kg^-1 of crystalloids in 10 (FC₁₀) or 20 (FC₂₀) minutes, in a random order. Fluid responsiveness was defined as stroke volume index increase ≥ 10%. We assessed the net area under the curve (AUC), the maximal percentage di

SUBMITTER: Messina A 

PROVIDER: S-EPMC8423602 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature