Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population.

ABSTRACT: FKBP5 gene-environment interaction (cG × E) studies have shown diverse results, some indicating significant interaction effects between the gene and environmental stressors on depression, while others lack such results. Moreover, FKBP5 has a potential role in the diathesis stress and differential susceptibility theorem. The aim of the present study was to evaluate whether a cG × E interaction effect of FKBP5 single-nucleotide polymorphisms (SNPs) or haplotype and early life stress (ELS) on depressive symptoms among young adults was moderated by a positive parenting style (PASCQ^pos), through the frameworks of the diathesis stress and differential susceptibility theorem. Data were obtained from the Survey of Adolescent Life in Västmanland Cohort Study, including 1006 participants

SUBMITTER: Keijser R 

PROVIDER: S-EPMC8423649 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature