Association of maternal vitamin B₁₂ and folate levels in early pregnancy with gestational diabetes: a prospective UK cohort study (PRiDE study).

ABSTRACT:

Aims/hypothesis

The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide in all ethnic groups. Low vitamin B₁₂ and low/high folate levels may contribute to GDM risk, but there is conflicting evidence. Our aim is to assess the relationships of early pregnancy vitamin B₁₂ and folate levels with the risk of GDM status at 26-28 weeks of gestation.

Methods

This was a prospective, multi-centre, multi-ethnic cohort study (n = 4746) in the UK. Participants who were eligible to be selectively screened as per the National Institute for Health and Care Excellence (NICE) criteria were included in the study.

Results

GDM prevalence was 12.5% by NICE and 14.7% by International Association of Diabetes and Pregnancy Study Groups (IADPSG) crit

SUBMITTER: Saravanan P 

PROVIDER: S-EPMC8423653 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature