Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.

ABSTRACT: Bile acid profiles are altered in obese individuals with asthma. Thus, we sought to better understand how obesity-related systemic changes contribute to lung pathophysiology. We also test the therapeutic potential of nitro-oleic acid (NO₂-OA), a regulator of metabolic and inflammatory signaling pathways, to mitigate allergen and obesity-induced lung function decline in a murine model of asthma. Bile acids were measured in the plasma of healthy subjects and individuals with asthma and serum and lung tissue of mice with and without allergic airway disease (AAD). Lung function, indices of inflammation and hepatic bile acid enzyme expression were measured in obese mice with house dust mite-induced AAD treated with vehicle or NO₂-OA. Serum levels of glycocholic acid and gl

SUBMITTER: Manni ML 

PROVIDER: S-EPMC8423735 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature