Sex Differences in Molecular Rhythms in the Human Cortex.

ABSTRACT:

Background

Diurnal rhythms in gene expression have been detected in the human brain. Previous studies found that males and females exhibit 24-hour rhythms in known circadian genes, with earlier peak expression in females. Whether there are sex differences in large-scale transcriptional rhythms in the cortex that align with observed sex differences in physiological and behavioral rhythms is currently unknown.

Methods

Diurnal rhythmicity of gene expression was determined for males and females using RNA sequencing data from human postmortem dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC). Sex differences among rhythmic genes were determined using significance cutoffs, threshold-free analyses, and R² difference. Phase concordance was assesse

SUBMITTER: Logan RW 

PROVIDER: S-EPMC8423868 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature