Pregnancy Serum DLK1 Concentrations Are Associated With Indices of Insulin Resistance and Secretion.

ABSTRACT:

Context

Delta like noncanonical notch ligand 1 (DLK1) is a paternally expressed imprinted gene that encodes an epidermal growth factor repeat-containing transmembrane protein. A bioactive, truncated DLK1 protein is present in the circulation and has roles in development and metabolism.

Objective

We sought to investigate links between maternal pregnancy circulating DLK1 concentrations and: (1) maternal and fetal DLK1 genotypes, (2) maternal insulin resistance and secretion, and (3) offspring size at birth.

Patients, design, and setting

We measured third-trimester maternal serum DLK1 concentrations and examined their associations with parentally transmitted fetal and maternal DLK1 genotypes, indices of maternal insulin resistance and secretion derived from 75-g oral glu

SUBMITTER: Petry CJ 

PROVIDER: S-EPMC8424055 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature