Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics.

ABSTRACT: As one of the major approaches in combating the COVID-19 pandemics, the availability of specific and reliable assays for the SARS-CoV-2 viral genome and its proteins is essential to identify the infection in suspected populations, make diagnoses in symptomatic or asymptomatic individuals, and determine clearance of the virus after the infection. For these purposes, use of the quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) for detection of the viral nucleic acid remains the most valuable in terms of its specificity, fast turn-around, high-throughput capacity, and reliability. It is critical to update the sequences of primers and probes to ensure the detection of newly emerged variants. Various assays for increased levels of IgG or IgM antibodies are available for det

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8424153 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature