Cognitive Trajectories and Dementia Risk: A Comparison of Two Cognitive Reserve Measures.

ABSTRACT:

Background and objectives

Cognitive reserve (CR) is meant to account for the mismatch between brain damage and cognitive decline or dementia. Generally, CR has been operationalized using proxy variables indicating exposure to enriching activities (activity-based CR). An alternative approach defines CR as residual variance in cognition, not explained by the brain status (residual-based CR). The aim of this study is to compare activity-based and residual-based CR measures in their association with cognitive trajectories and dementia. Furthermore, we seek to examine if the two measures modify the impact of brain integrity on cognitive trajectories and if they predict dementia incidence independent of brain status.

Methods

We used data on 430 older ad

SUBMITTER: Gallo F 

PROVIDER: S-EPMC8424183 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature