Susceptibility of CTLA-4 -1661A/G polymorphism towards severity of rheumatic heart disease.

ABSTRACT:

Aim

Genetic contribution in acute rheumatic fever (ARF)/rheumatic heart disease (RHD) has been suggested but not according to severity of the valve involvement. This study attempts to identify the relevance of CTLA-4 polymorphism with severity of the disease.

Methods

In a case-control design, 291 healthy controls and 83 patients were genotyped for association between RHD and single-nucleotide polymorphisms -1661A/G of CTLA-4.

Results

Segregation of patients on the basis of severity i.e., MVL (Mitral Valve Lesion) and CVL (Combined Valve Lesion) revealed that the frequency of CTLA-4 -1661G allele depleted as the disease progressed to CVL (p < 0.05). Patients in the age group of 31-45 years were significantly more susceptible (p < 0.046). Whereas, female patients were m

SUBMITTER: Bansal A 

PROVIDER: S-EPMC8424281 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature