Computational methods for the prediction of chromatin interaction and organization using sequence and epigenomic profiles.

ABSTRACT: The exploration of three-dimensional chromatin interaction and organization provides insight into mechanisms underlying gene regulation, cell differentiation and disease development. Advances in chromosome conformation capture technologies, such as high-throughput chromosome conformation capture (Hi-C) and chromatin interaction analysis by paired-end tag (ChIA-PET), have enabled the exploration of chromatin interaction and organization. However, high-resolution Hi-C and ChIA-PET data are only available for a limited number of cell lines, and their acquisition is costly, time consuming, laborious and affected by theoretical limitations. Increasing evidence shows that DNA sequence and epigenomic features are informative predictors of regulatory interaction and chromatin architecture. Based o

SUBMITTER: Tao H 

PROVIDER: S-EPMC8424394 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature