Osteogenesis and angiogenesis of a bulk metallic glass for biomedical implants.

ABSTRACT: Implantation is an essential issue in orthopedic surgery. Bulk metallic glasses (BMGs), as a kind of novel materials, attract lots of attentions in biological field owing to their comprehensive excellent properties. Here, we show that a Zr₆₁Ti₂Cu₂₅Al₁₂ (at. %) BMG (Zr-based BMG) displays the best cytocompatibility, pronounced positive effects on cellular migration, and tube formation from in-vitro tests as compared to those of commercial-pure titanium and poly-ether-ether-ketone. The in-vivo micro-CT and histological evaluation demonstrate the Zr-based BMG can significantly promote a bone formation. Immunofluorescence tests and digital reconstructed radiographs manifest a stimulated effect on early blood vessel formation from the Zr

SUBMITTER: Sun K 

PROVIDER: S-EPMC8424448 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature