Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.

ABSTRACT:

Objective

To construct a polygenic risk score (PRS) for stroke and evaluate its utility in risk stratification and primary prevention for stroke.

Methods

Using a meta-analytic approach and large genome-wide association results for stroke and stroke-related traits in East Asians, we generated a combined PRS (metaPRS) by incorporating 534 genetic variants in a training set of 2,872 patients with stroke and 2,494 controls. We then validated its association with incident stroke using Cox regression models in large Chinese population-based prospective cohorts comprising 41,006 individuals.

Results

During a total of 367,750 person-years (mean follow-up 9.0 years), 1,227 participants developed stroke before age 80 years. Individuals with high polygenic risk had an about 2-fo

SUBMITTER: Lu X 

PROVIDER: S-EPMC8424497 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature