The dual role of phytochemicals on SARS-CoV-2 inhibition by targeting host and viral proteins.

ABSTRACT:

Background

The severe acute respiratory syndrome-2019 has affected more than 190 million people around the world and caused severe crises throughout the globe. Due to rapid mutation in the viral genome, its became important to simultaneously improvise the host immunity while targeting viral proteins to reduce the severity of infection.

Aim

The current computational work focuses on multi-level rigorous screening of 47 medicinal plant-based phytochemicals for discovering effective phytochemical inhibitors against the host and viral targets.

Experimental procedure

A total of 586 phytochemicals were analyzed in detail based on their drug-likeness, pharmacological properties, and structure-based activity against the viral proteins (Spike glycoprotein, Papain-like protease,

SUBMITTER: Singh P 

PROVIDER: S-EPMC8424525 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature