Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators.

ABSTRACT: Increasing attention has been recently devoted to ⁸⁹Zr(IV) and ⁶⁸Ga(III) radionuclides, due to their favorable decay characteristics for positron emission tomography (PET). In the present paper, a deep investigation is presented on Ga(III) and Zr(IV) complexes with a series of tri-(H₃L1, H₃L3, H₃L4 and desferrioxamine E, DFOE) and tetrahydroxamate (H₄L2) ligands. Herein, we describe the rational design and synthesis of two cyclic complexing agents (H₃L1 and H₄L2) bearing three and four hydroxamate chelating groups, respectively. The ligand structures allow us to take advan

SUBMITTER: Toporivska Y 

PROVIDER: S-EPMC8424644 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature