Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer.

ABSTRACT: Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells and immune cells in a variety of different ways, leading to either a pro-tumor or antitumor effect. Tumor-infiltrating CD8⁺ T cells and natural killer (NK) cells perform as effector cells against tumor cells and are associated with better clinical outcome. Immunotherapy approaches that improve the antitumor activity and proliferation of CD8⁺ T and NK cells include PD-1/PD-L1 blockade, CAR T cell therapy, or ex vivo-stimulated NK cells. A subset of CD8⁺ T cells, tissue-resident memory T cells, has also recently been associated with good prognosis in breast cancer patients, and

SUBMITTER: Nelson MA 

PROVIDER: S-EPMC8424653 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature