Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase.

ABSTRACT:

Purpose

We evaluated effects of asparaginase dosage, schedule, and formulation on CSF asparagine in children with acute lymphoblastic leukemia (ALL).

Methods

We evaluated CSF asparagine (2114 samples) and serum asparaginase (5007 samples) in 482 children with ALL treated on the Total XVI study (NCT00549848). Patients received one or two 3000 IU/m² IV pegaspargase doses during induction and were then randomized in continuation to receive 2500 IU/m² or 3500 IU/m² IV intermittently (four doses) on the low-risk (LR) or continuously (15 doses) on the standard/high risk (SHR) arms. A pharmacokinetic-pharmacodynamic model was used to estimate the duration of CSF asparagine depletion below 1 uM.

Results

During induction, CSF asparagine depleti

SUBMITTER: Panetta JC 

PROVIDER: S-EPMC8424750 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature