Liver dysfunction in idiopathic pulmonary arterial hypertension: prevalence, characteristics and prognostic significance, a retrospective cohort study in China.

ABSTRACT:

Objectives

The aim was to elucidate the relationship between liver function and idiopathic pulmonary arterial hypertension (IPAH).

Design and setting

Retrospective, longitudinal study in urban tertiary care centre in Shanghai, China.

Participants

407 IPAH consecutive incident patients age 18-65 years were retrospectively enrolled from January 2008 to December 2018.

Outcome measurements

The primary endpoint was all-cause mortality. The cut-off value was determined by receiver operating characteristic curve (ROC), which was validated by Cox proportional hazard model was internally validated by bootstrap analysis and used for survival analysis. The Cox model was (internally) validated and cross-validated areas under the curve (AUC) should be reported.

Results</

SUBMITTER: Luo C 

PROVIDER: S-EPMC8424845 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature