ACBD3 modulates KDEL receptor interaction with PKA for its trafficking via tubulovesicular carrier.

ABSTRACT:

Background

KDEL receptor helps establish cellular equilibrium in the early secretory pathway by recycling leaked ER-chaperones to the ER during secretion of newly synthesized proteins. Studies have also shown that KDEL receptor may function as a signaling protein that orchestrates membrane flux through the secretory pathway. We have recently shown that KDEL receptor is also a cell surface receptor, which undergoes highly complex itinerary between trans-Golgi network and the plasma membranes via clathrin-mediated transport carriers. Ironically, however, it is still largely unknown how KDEL receptor is distributed to the Golgi at steady state, since its initial discovery in late 1980s.

Results

We used a proximity-based in vivo tagging strategy to further dissect mechanisms of

SUBMITTER: Yue X 

PROVIDER: S-EPMC8424950 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature