The circular RNA circCPE regulates myoblast development by sponging miR-138.

ABSTRACT:

Background

Skeletal muscle development, a long-term and complex process, is controlled by a set of the myogenic genes. Circular RNAs (circRNAs), a class of noncoding RNA, have been shown to regulate various biological processes. Recent studies indicate circRNAs may be involved in myogenesis, but the role and regulatory mechanism of circRNAs in myogenesis is largely unknown. In the present study, circCPE was firstly found to promote the bovine myoblast proliferation and inhibit cell apoptosis and differentiation by influencing the expression of FOXC1 in a miR138-mediated manner. And in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle regeneration.

Results

We identified a novel circular RNA circCPE by analyzing circRNAs sequencing data of bov

SUBMITTER: Ru W 

PROVIDER: S-EPMC8424951 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature