Dendritic cells matured with recombinant human sperm associated antigen 9 (rhSPAG9) induce CD4⁺, CD8⁺ T cells and activate NK cells: a potential candidate molecule for immunotherapy in cervical cancer.

ABSTRACT:

Background

Dendritic cell (DC)-based immunotherapy is capable of activating the immune system and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. However, major limitations are the availability of autologous tumor cells as antigenic source and the selection of antigen that may have potential to activate both CD4⁺ and CD8⁺ T cells in immune-specific manner. Recently, we reported the expression of sperm associated antigen 9 (SPAG9) that is associated with various types of malignancies including cervical cancer. We examined the recombinant human SPAG9 (rhSPAG9) as an antigenic source for generating efficient DCs to stimulate CD4⁺ and CD8⁺ T cell responses for future DCs-based vaccine trials in cervical can

SUBMITTER: Dhandapani H 

PROVIDER: S-EPMC8424976 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature