Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response.

ABSTRACT:

Background

Tumor-derived exosomes (TEXs) are involved in tumor progression and the immune modulation process and mediate intercellular communication in the tumor microenvironment. Although exosomes are considered promising liquid biomarkers for disease diagnosis, it is difficult to discriminate TEXs and to develop TEX-based predictive biomarkers.

Methods

In this study, the gene expression profiles and clinical information were collected from The Cancer Genome Atlas (TCGA) database, IMvigor210 cohorts, and six independent Gene Expression Omnibus datasets. A TEXs-associated signature named TEXscore was established to predict overall survival in multiple cancer types and in patients undergoing immune checkpoint blockade therapies.

Results

Based on exosome-associated gene

SUBMITTER: Wu J 

PROVIDER: S-EPMC8424990 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature