Recovering genotypes and phenotypes using allele-specific genes.

ABSTRACT: With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum.

SUBMITTER: Gursoy G 

PROVIDER: S-EPMC8425091 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature