Recovering genotypes and phenotypes using allele-specific genes.
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ABSTRACT:
SUBMITTER: Gursoy G
PROVIDER: S-EPMC8425091 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Recovering genotypes and phenotypes using allele-specific genes.
Gürsoy Gamze G Lu Nancy N Wagner Sarah S Gerstein Mark M
Genome biology 20210907 1
With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum. ...[more]
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