Genomic and functional characterization of five novel Salmonella-targeting bacteriophages.

ABSTRACT:

Background

The host-unrestricted, non-typhoidal Salmonella enterica serovar Enteritidis (S. Enteritidis) and the serovar Typhimurium (S. Typhimurium) are major causative agents of food-borne gastroenteritis, and the host-restricted Salmonella enterica serovar Gallinarum (S. Gallinarum) is responsible for fowl typhoid. Increasing drug resistance in Salmonella contributes to the reduction of effective therapeutic and/or preventive options. Bacteriophages appear to be promising antibacterial tools, able to combat infectious diseases caused by a wide range of Salmonella strains belonging to both host-unrestricted and host-restricted Salmonella serovars.

Methods

In this study, five novel lytic Salmonella phages, named UPWr_S1-5, were isolated and characterized, including host ran

SUBMITTER: Kuzminska-Bajor M 

PROVIDER: S-EPMC8425127 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature