Xanthine dehydrogenase as a prognostic biomarker related to tumor immunology in hepatocellular carcinoma.

ABSTRACT:

Background

Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system. However, the prognostic value of XDH in predicting tumor-infiltrating lymphocyte abundance, the immune response, and survival in different cancers, including hepatocellular carcinoma (HCC), is still unclear.

Methods

XDH expression was analyzed in multiple databases, including Oncomine, the Tumor Immune Estimation Resource (TIMER), the Kaplan-Meier plotter database, the Gene Expression Profiling Interactive Analysis (GEPIA) database, and The Cancer Genome Atlas (TCGA). XDH-associated transcriptional profiles were detected with an mRNA array, and the levels of infiltrating immune cells were valid

SUBMITTER: Lin Z 

PROVIDER: S-EPMC8425161 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature