Functional profiles of Mullerian inhibiting substance/anti-Mullerian hormone (MIS/AMH) in primarily cultured endometrial cancer cells.

ABSTRACT: Background: Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) inhibits proliferation of MIS/AMH receptor-expressing gynecologic tumors in vivo and in vitro, but the underlying mechanisms have not been fully defined. This study aimed to investigate the expression of MIS/AMH type II receptor (MIS/AMHRII) in endometrial cancer, to identify the mechanism of growth inhibition in MIS/AMH-treated endometrial cancer cells, and to evaluate the clinical significance of MIS/AMH as an effective targeted therapy for MIS/AMH receptor-expressing tumors. Methods: We used tissue samples from 10 patients with total hysterectomy for endometrial cancer. To identify involved signaling pathways, we performed western blotting on apoptosis-, cell cycle-, Wnt signaling-, a

SUBMITTER: Kim SI 

PROVIDER: S-EPMC8425195 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature