The association of FMR1 gene (CGG)n variation with idiopathic female infertility.

ABSTRACT:

Introduction

The FMR1 gene plays an important role in brain development and in the regulation of ovarian function. The FMR1 gene contains CGG repeat variation and the expansion of the repeats is associated with various phenotypes e.g. fragile X syndrome, premature ovarian failure, etc. Repeats ranging < 55 CGG are considered normal, however recent studies suggest that high-normal (35-54 CGG) and low-normal (< 26 CGG) alleles may also have an impact on female reproductive function.

Material and methods

We have performed a case-control study to assess the impact of FMR1 gene CGG repeats on female infertility. The study comprised 161 women with primary and secondary idiopathic infertility and 12 females with diminished ovarian reserve. The control group con

SUBMITTER: Grasmane A 

PROVIDER: S-EPMC8425234 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature