Efficacy and harms of convalescent plasma for treatment of hospitalized COVID-19 patients: a systematic review and meta-analysis.

ABSTRACT:

Introduction

We systematically reviewed benefits and harms of convalescent plasma (CP) in hospitalized COVID-19 patients.

Material and methods

Randomized controlled trials (RCTs) and observational studies assessing CP effects on hospitalized, adult COVID-19 patients were searched until November 24, 2020. We assessed risk of bias (RoB) using Cochrane RoB 2.0 and ROBINS-I tools. Inverse variance random effect meta-analyses were performed. Quality of evidence was evaluated using GRADE methodology. Primary outcomes were all-cause mortality, clinical improvement, and adverse events.

Results

Five RCTs (n = 1067) and 6 cohorts (n = 881) were included. Three and 1 RCTs had some concerns and high RoB, respectively; and there was serious RoB in all cohorts. Conval

SUBMITTER: Piscoya A 

PROVIDER: S-EPMC8425263 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature