T cells mediate cell non-autonomous arterial ageing in mice.

ABSTRACT:

Key points

Increased large artery stiffness and impaired endothelium-dependent dilatation occur with advanced age. We sought to determine whether T cells mechanistically contribute to age-related arterial dysfunction. We found that old mice exhibited greater proinflammatory T cell accumulation around both the aorta and mesenteric arteries. Pharmacologic depletion or genetic deletion of T cells in old mice resulted in ameliorated large artery stiffness and greater endothelium-dependent dilatation compared with mice with T cells intact.

Abstract

Ageing of the arteries is characterized by increased large artery stiffness and impaired endothelium-dependent dilatation. T cells contribute to hypertension in acute rodent models but whether they contribute to chronic age-related art

SUBMITTER: Trott DW 

PROVIDER: S-EPMC8425389 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature